pERKing up the BLIMP in plasma cell differentiation.

  title={pERKing up the BLIMP in plasma cell differentiation.},
  author={David M. Allman and Michael P Cancro},
  journal={Science signaling},
  volume={4 169},
The intracellular pathways that induce the differentiation of naïve B cells into antibody-secreting plasma cells remain poorly defined. A new study now provides surprising evidence that the activation of extracellular signal-regulated kinase (ERK) is pivotal for inducing the transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp-1), which is required for plasma cell differentiation. Consequently, ERK-deficient B cells were unable to generate plasma cells effectively. This is… CONTINUE READING