pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis.

@article{Kafaja2018pDCsIL,
  title={pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis.},
  author={Suzanne Kafaja and Isela Valera and Anagha A. Divekar and Rajan Saggar and Fereidoun Abtin and Daniel e. Furst and Dinesh Khanna and Ram Raj Singh},
  journal={JCI insight},
  year={2018},
  volume={3 9}
}
Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear. We demonstrate that, in animals and humans with systemic fibrosis, plasmacytoid DCs (pDCs) are unaffected or are reduced systemically (spleen/peripheral blood), but they increase in the affected organs (lungs/skin/bronchoalveolar lavage). A pivotal role of pDCs… CONTINUE READING