pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia

@article{Deev2015pCMVvegf165IG,
  title={pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia},
  author={Roman V. Deev and Ilia Y. Bozo and Nina D. Mzhavanadze and D. A. Voronov and Aleksandr V. Gavrilenko and Yu. V. Chervyakov and Ilia N. Staroverov and Roman E. Kalinin and P G Shvalb and A. A. Isaev},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  year={2015},
  volume={20},
  pages={473 - 482}
}
  • R. DeevI. Y. Bozo A. Isaev
  • Published 13 March 2015
  • Medicine, Biology
  • Journal of Cardiovascular Pharmacology and Therapeutics
Effective treatment of chronic lower limb ischemia is one of the most challenging issues confronting vascular surgeons. There are a number of choices available to the vascular surgeon. Open or endovascular revascularization is the treatment of choice when applicable. Current pharmacological therapies play an auxiliary role and cannot prevent disease progression. Therefore, new methods of treatment are needed. We conducted a phase 2b/3 multicenter randomized controlled clinical trial of the… 
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Pain-free walking distance (PWD), blood flow linear velocity (BFLV), and ankle-brachial index (ABI) were monitored for 6 months and the greatest therapeutic effect was observed for stage III disease: PWD increased by 683% and the mean value was unchanged in the control group.

Results of 5-year follow-up study in patients with peripheral artery disease treated with PL-VEGF165 for intermittent claudication

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The recent advances in proangiogenic gene therapy for critical limb ischemia and DNA vaccine for hypertension are discussed.

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The quality of the evidence is low due to risk of bias and imprecision, however, growth factors may decrease the rate of any limb amputations and the direction and size of effects for growth factors on serious adverse events are uncertain.

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The concept of angiogenic therapy as a sole treatment is re-evaluated and a combination with regenerative therapies or standard revascularization operations might be needed to improve tissue function and clinical benefits.

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Terapia gênica de isquemia de membro é uma realidade?

The first clinical evidence of the effects of gene therapy with vascular endothelial growth factor (VEGF) was observed in patients with peripheral artery disease and can be concluded that angiogenic therapy is a reality?

Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor-Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy.

Results suggest that minicircle-mediated VEGF gene delivery, combined with the unique properties of human MSC, could represent a promising ex vivo gene therapy approach for an improved angiogenesis in the context of PAD.

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