p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

@article{Le2012p90RSKTT,
  title={p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.},
  author={Nhat-Tu Le and Yuichiro Takei and Tetsuro Shishido and C F Woo and Eugene Chang and Kyung-Sun Heo and Hakjoo Lee and Yan Lu and Craig N. Morrell and Masayoshi Oikawa and Carolyn McClain and Xin Wang and Cathy Tournier and Carlos Alberto Molina and Jack Taunton and Chen Yan and Keigi Fujiwara and C. G. Patterson and Jay Yang and Jun-ichi Abe},
  journal={Circulation research},
  year={2012},
  volume={110 4},
  pages={536-50}
}
RATIONALE Cardiomyocyte apoptosis is one of the key events in the development and progression of heart failure, and a crucial role for ICER (inducible cAMP early repressor) in this process has been previously reported. ERK5 is known to inhibit cardiac apoptosis after myocardial infarction (MI), especially in hyperglycemic states, via association with CHIP ubiquitin (Ub) ligase and subsequent upregulation of CHIP ligase activity, which induces ICER ubiquitination and subsequent protein… CONTINUE READING

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