p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1.

@article{Takahashi1999p90RSKIA,
  title={p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1.},
  author={Eiichi Takahashi and Jun-ichi Abe and Byron M. Gallis and Ruedi Aebersold and D J Spring and Edwin G. Krebs and Bradford C. Berk},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 29},
  pages={
          20206-14
        }
}
The Na+/H+ exchanger isoform-1 (NHE-1) is the key member of a family of exchangers that regulates intracellular pH and cell volume. Activation of NHE-1 by growth factors is rapid, correlates with increased NHE-1 phosphorylation and cell alkalinization, and plays a role in cell cycle progression. By two-dimensional tryptic peptide mapping of immunoprecipitated NHE-1, we identify serine 703 as the major serum-stimulated amino acid. Mutation of serine 703 to alanine had no effect on acid… CONTINUE READING
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