p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation.

@article{Song2007p85alphaAA,
  title={p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation.},
  author={Lun Song and Jingxia Li and Jianping Ye and Gang Yu and Jin Ding and Dongyun Zhang and Weiming Ouyang and Ziming Dong and Sung Ouk Kim and Chuanshu Huang},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 7},
  pages={2713-31}
}
Apoptosis is an important cellular response to UV radiation (UVR), but the corresponding mechanisms remain largely unknown. Here we report that the p85alpha regulatory subunit of phosphatidylinositol 3-kinase (PI-3K) exerted a proapoptotic role in response to UVR through the induction of tumor necrosis factor alpha (TNF-alpha) gene expression. This special effect of p85alpha was unrelated to the PI-3K-dependent signaling pathway. Further evidence demonstrated that the inducible transcription… CONTINUE READING