p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.

@article{Vasseur2004p8IP,
  title={p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.},
  author={Sophie Vasseur and Emma Folch-Puy and Verena Hlouschek and S Hern{\'a}ndez Garc{\'i}a and Fritz Fiedler and Markus M. Lerch and Jean Charles Dagorn and Daniel Closa and Juan Iovanna},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 8},
  pages={7199-207}
}
p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis. A p8-deficient mouse strain was generated as a tool to investigate its function. Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic… CONTINUE READING

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