p75NTR Is Positively Promiscuous Novel Partners and New Insights

  title={p75NTR Is Positively Promiscuous Novel Partners and New Insights},
  author={Philip A. Barker},

Figures from this paper

The p75 neurotrophin receptor.

p75NTR – live or let die

An All-Purpose Tool for Axon Guidance

Recent studies reveal that p75NTR is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.

Understanding proneurotrophin actions: Recent advances and challenges

Emerging evidence for a novel transmembrane mechanism for ligand‐specific p75NTR activation and several mechanisms by which p 75NTR‐dependent apoptotic and nonapoptotic responses can be selective activated are reviewed.

The function of p75NTR in glia

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

It is highlighted that the generation of the intracellular domain fragment of p75NTR is associated with many of the receptor functions, regardless of its ligand and co‐receptor interactions.

Heterodimerization of p45–p75 Modulates p75 Signaling: Structural Basis and Mechanism of Action

The formation of a p45-p75 heterodimer overrides p75’s inhibition of nerve regeneration by stopping p75 homodimers from forming and creating a complex with the Nogo receptor.

Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors.

The biological significance and potential of inhibiting the interaction between p75(NTR) and PDE4A for the development of an isoform-specific inhihibitor for PDEs are discussed.

The yin and yang of neurotrophin action

The proteolytic cleavage of proneurotrophins represents a mechanism that controls the direction of action of neurotrophins and has profound implications for the understanding of the role of neurotrophic molecules in a wide range of cellular processes.

Metalloproteases and γ‐secretase: new membrane partners regulating p75 neurotrophin receptor signaling?

It is argued that both sheddases and γ‐secretase are key membrane components regulating p75‐mediated signaling transduction; therefore, further attention should be paid to their roles as p75 signaling regulators.



CRNF, a Molluscan Neurotrophic Factor That Interacts with the p75 Neurotrophin Receptor

CRNF bound to p75 with nanomolar affinity but was not similar in sequence to neurotrophins or any other known gene product, suggesting it may represent the prototype of another family of p75 ligands.

Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system

Mice homozygous for this mutation lack both protein isoforms, display severe nervous system defects and reveal a previously unknown role of p75NTR in the formation of blood vessels.

p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

Interference with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin.

A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

It is reported that the p75 neurotrophin receptor (p75NTR) is a co-receptor of NgR for MAG signaling and a potential therapeutic target for promoting nerve regeneration.

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

It is shown that direct interaction of the Rho GDP dissociation inhibitor (Rho-GDI) with p75NTR initiates the activation of RhoA, and this interaction between p 75NTR and Rho- GDI is strengthened by MAG or Nogo, which has potential as a therapeutic agent against the inhibitory cues that block regeneration in the central nervous system.

Regulation of Cell Survival by Secreted Proneurotrophins

It is shown that the proforms of nerve growth factor (NGF) and the pro forms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix metalloproteinases (MMPs).

Sortilin is essential for proNGF-induced neuronal cell death

It is reported that proNGF creates a signalling complex by simultaneously binding to p 75NTR and sortilin, which acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGf.

The Neurotrophin Receptor p75NTR as a Positive Modulator of Myelination

The results show that myelin formation is inhibited in the absence of functional p75NTR and enhanced by blocking TrkC activity, and the enhancement of myelination by endogenous brain-derived neurotrophic factor is mediated by the p 75NTR receptor, whereas Trk C receptors are responsible for neurotrophin-3 inhibition.

Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

Neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.