p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

  title={p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp},
  author={Kevin C. Wang and Jieun A. Kim and Rajeev Sivasankaran and Rosalind A. Segal and Zhigang He},
In inhibiting neurite outgrowth, several myelin components, including the extracellular domain of Nogo-A (Nogo-66), oligodendrocyte myelin glycoprotein (OMgp) and myelin-associated glycoprotein (MAG), exert their effects through the same Nogo receptor (NgR). The glycosyl phosphatidylinositol (GPI)-anchored nature of NgR indicates the requirement for additional transmembrane protein(s) to transduce the inhibitory signals into the interior of responding neurons. Here, we demonstrate that p75, a… 

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