p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

@article{Hamanoue1999p75MediatedNA,
  title={p75-Mediated NF-$\kappa$B Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor},
  author={Makoto Hamanoue and Gayle Middleton and Sean Wyatt and Ellis G. Jaffray and Ronald Thomas Hay and Alun M. Davies},
  journal={Molecular and Cellular Neuroscience},
  year={1999},
  volume={14},
  pages={28-40}
}
We have investigated whether the transcription factor NF-kappaB plays a role in regulating neuronal survival by manipulating NF-kappaB activation in the nerve growth factor (NGF)-dependent sensory neurons of the embryonic mouse trigeminal ganglion. Overexpression of either the p65 or the p50 NF-kappaB subunits resulted in NF-kappaB activation and promoted in vitro survival as effectively as NGF. Expression of a superrepressor IkappaB-alpha protein prevented NF-kappaB activation in p65/p50… 
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