p73 loss triggers conversion to squamous cell carcinoma reversible upon reconstitution with TAp73alpha.

@article{Johnson2007p73LT,
  title={p73 loss triggers conversion to squamous cell carcinoma reversible upon reconstitution with TAp73alpha.},
  author={Jodi Smith Johnson and James P Lagowski and Alexandra Appelgren Sundberg and Sarah Lawson and Yuangang Liu and Molly Kulesz-Martin},
  journal={Cancer research},
  year={2007},
  volume={67 16},
  pages={
          7723-30
        }
}
The expression level of the p53 family member, p73, is frequently deregulated in human epithelial cancers, correlating with tumor invasiveness, therapeutic resistance, and poor patient prognosis. However, the question remains whether p73 contributes directly to the process of malignant conversion or whether aberrant p73 expression represents a later selective event to maintain tumor viability. We explored the role of p73 in malignant conversion in a clonal model of epidermal carcinogenesis… CONTINUE READING

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