p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

  title={p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage},
  author={Z. Yuan and H. Shioya and T. Ishiko and X. Sun and J. Gu and Y. Huang and H. Lu and S. Kharbanda and Ralph W. Weichselbaum and D. Kufe},
  • Z. Yuan, H. Shioya, +7 authors D. Kufe
  • Published 1999
  • Biology, Medicine
  • Nature
  • The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein but, unlike p53, it is not induced in response to DNA damage,. The tyrosine kinase c-Abl is activated by certain DNA-damaging agents and contributes tothe induction of programmed cell death (apoptosis) by p53-dependent and p53-independent mechanisms. Here we show that c-Abl binds to p73 in cells, interacting through its SH3 domain with the carboxy-terminal homo-oligomerization domain of p73. c-Abl… CONTINUE READING
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