p73 is a human p53-related protein that can induce apoptosis

  title={p73 is a human p53-related protein that can induce apoptosis},
  author={Christine A. Jost and Maria Del Carmen Marin and William G Kaelin},
The protein p53 is the most frequently mutated tumour suppressor to be identified so far in human cancers,. The ability of p53 to inhibit cell growth is due, at least in part, to its ability to bind to specific DNA sequences and activate the transcription of target genes such as that encoding the cell-cycle inhibitor p21Waf1/Cip1 (ref. 3). A gene has recently been identified that is predicted to encode a protein with significant amino-acid sequence similarity to p53 (ref. 4). In particular… CONTINUE READING


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