p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent

@article{Ichimiya1999p73AC,
  title={p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent},
  author={Shingo Ichimiya and Yoshinori Nimura and Hajime Kageyama and Naoyuki Takada and Masao Sunahara and Tomotane Shishikura and Yohko Nakamura and Shigeru Sakiyama and Naohiko Seki and Miki Ohira and Yasuhiko Kaneko and Frank McKeon and Daniel Caput and Akira Nakagawara},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1061-1066}
}
p73, a novel p53 family member, is a recently identified candidate neuroblastoma (NBL) suppressor gene mapped at chromosome 1p36.33 and was found to inhibit growth and induce apoptosis in cell lines. To test the hypothesis that p73 is a NBL suppressor gene, we analysed the p73 gene in primary human NBLs. Loss of heterozygosity (LOH) for p73 was observed in 19% (28/151) of informative cases which included 92 mass-screening (MS) tumors. The high frequency of p73 LOH was significantly associated… CONTINUE READING