p73α Regulation by Chk1 in Response to DNA Damage

@inproceedings{Gonzlez2003p73RB,
  title={p73α Regulation by Chk1 in Response to DNA Damage},
  author={Susana Gonz{\'a}lez and Carol Prives and Carlos Cordon-Cardo},
  year={2003}
}
In eukaryotes, damaged DNA can initiate a signaling pathway resulting in cell cycle arrest or, in the case of irreparable damage, in cell death. Because DNA damage can be caused by myriad types of assaults, multiple signals might be triggered. While some signaling pathways are poorly understood, there has been significant progress in elucidating pathways involving the ATM and ATR mediator protein kinases and their downstream effector kinases Chk1 (34) and Chk2 (27). The p53 tumor suppressor… CONTINUE READING

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