p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K.

@article{SnchezMargalet1999p68SI,
  title={p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K.},
  author={V{\'i}ctor S{\'a}nchez-Margalet and Souad Najib},
  journal={FEBS letters},
  year={1999},
  volume={455 3},
  pages={307-10}
}
The 68 kDa Src substrate associated during mitosis is an RNA binding protein with Src homology 2 and 3 domain binding sites. A role for Src associated in mitosis 68 as an adaptor protein in signaling transduction has been proposed in different systems such as T-cell receptors. In the present work, we have sought to assess the possible role of Src associated in mitosis 68 in insulin receptor signaling. We performed in vivo studies in HTC-IR cells and in vitro studies using recombinant Src… CONTINUE READING