p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryos.

@article{Favetta2004p66shcBN,
  title={p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryos.},
  author={Laura A. Favetta and Claude Robert and Elizabeth J St John and Dean Harvey Betts and William Allan King},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 6},
  pages={383-92}
}
High embryo loss occurs in the first week of bovine embryo development, with a high percentage of embryonic arrest. We hypothesized that arrested embryos enter a 'senescence-like state' and that both the cell cycle regulatory protein p53 and the stress-related protein p66(shc), which are involved in the onset of senescence in somatic cells, are responsible for this early embryonic arrest. In our in vitro production system, 13.5 +/- 0.5% of embryos arrest at the 2-4-cell stage. First cleavage… CONTINUE READING

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