p63 transcriptional regulation of epithelial integrity and cancer.

  title={p63 transcriptional regulation of epithelial integrity and cancer.},
  author={Barry Trink and Motonobu Osada and Edward A. Ratovitski and David Sidransky},
  journal={Cell cycle},
  volume={6 3},
p63 plays a more complex role than initially thought in cancer and development. As a p53 homolog, p63 encodes transcription factors that primarily functions through regulation of downstream gene expression. However, p63 is also involved in RNA processing and activation of beta-catenin signaling. A number of genes activated by TAp63 support the notion that p63 is involved in tight transcriptional control of epithelial differentiation, cell adhesion, and tumorigenesis via cell cycle arrest… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…