p63 transcriptional regulation of epithelial integrity and cancer.

@article{Trink2007p63TR,
  title={p63 transcriptional regulation of epithelial integrity and cancer.},
  author={Barry Trink and Motonobu Osada and Edward A. Ratovitski and David Sidransky},
  journal={Cell cycle},
  year={2007},
  volume={6 3},
  pages={240-5}
}
p63 plays a more complex role than initially thought in cancer and development. As a p53 homolog, p63 encodes transcription factors that primarily functions through regulation of downstream gene expression. However, p63 is also involved in RNA processing and activation of beta-catenin signaling. A number of genes activated by TAp63 support the notion that p63 is involved in tight transcriptional control of epithelial differentiation, cell adhesion, and tumorigenesis via cell cycle arrest… CONTINUE READING

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