p63 regulates proliferation and differentiation of developmentally mature keratinocytes.

  title={p63 regulates proliferation and differentiation of developmentally mature keratinocytes.},
  author={Amy B. Truong and Markus Kretz and Todd W Ridky and Robin Kimmel and Paul A. Khavari},
  journal={Genes & development},
  volume={20 22},
p63 is a multi-isoform p53 family member required for epidermal development. Contrasting roles for p63 in either the initial commitment to the stratified epithelial cell fate or in stem cell-based self-renewal have been proposed. To investigate p63 function in a post-developmental context, we used siRNAs directed against p63 to down-regulate p63 expression in regenerating human epidermis. Loss of p63 resulted in severe tissue hypoplasia and inhibited both stratification and differentiation in a… CONTINUE READING
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