p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.

@article{Pyati2011p63MA,
  title={p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.},
  author={Ujwal J. Pyati and Evisa Gjini and Seth Carbonneau and Jeong-Soo Lee and Feng Guo and Cicely A. Jette and David P Kelsell and A Thomas Look},
  journal={Developmental cell},
  year={2011},
  volume={21 3},
  pages={492-505}
}
Endoplasmic reticulum (ER) stress triggers tissue-specific responses that culminate in either cellular adaptation or apoptosis, but the genetic networks distinguishing these responses are not well understood. Here we demonstrate that ER stress induced in the developing zebrafish causes rapid apoptosis in the brain, spinal cord, tail epidermis, lens, and epiphysis. Focusing on the tail epidermis, we uncover an apoptotic response that depends on Puma, but not on p53 or Chop. puma is… CONTINUE READING
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