p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

@article{Yang1999p63IE,
  title={p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development},
  author={Annie Yang and Ronen Schweitzer and Deqin Sun and Mourad Kaghad and Nancy L. Walker and Roderick Terry Bronson and Cliff Tabin and Arlene H Sharpe and Daniel Caput and Christopher P. Crum and Frank McKeon},
  journal={Nature},
  year={1999},
  volume={398},
  pages={714-718}
}
The p63 gene, a homologue of the tumour-suppressor p53 (refs 1–5), is highly expressed in the basal or progenitor layers of many epithelial tissues. Here we report that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development. p63 is expressed in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all sites of reciprocal signalling that direct morphogenetic patterning of the underlying mesoderm… CONTINUE READING
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