p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.

@article{Keyes2006p63HM,
  title={p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.},
  author={William M. Keyes and Hannes Vogel and Maranke I. Koster and Xuecui Guo and Yi Ling Qi and Kristin M Petherbridge and Dennis R. Roop and Allan Bradley and Alea A. Mills},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 22},
  pages={8435-40}
}
Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53 had fewer tumors than p53+/- mice. The rare tumors that developed in mice with… CONTINUE READING

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Development (Cambridge, U.K

  • T. Kurita, A. A. Mills, G. R. Cunha
  • 2004
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