p63 and p73: roles in development and tumor formation.

  title={p63 and p73: roles in development and tumor formation.},
  author={Ute M. Moll and Neda Slade},
  journal={Molecular cancer research : MCR},
  volume={2 7},
The tumor suppressor p53 is critically important in the cellular damage response and is the founding member of a family of proteins. All three genes regulate cell cycle and apoptosis after DNA damage. However, despite a remarkable structural and partly functional similarity among p53, p63, and p73, mouse knockout studies revealed an unexpected functional diversity among them. p63 and p73 knockouts exhibit severe developmental abnormalities but no increased cancer susceptibility, whereas this… CONTINUE READING
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