p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.

@article{Cancino2013p63RA,
  title={p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.},
  author={Gonzalo I. Cancino and Adelaide P. Yiu and Michael Patrick Fatt and Chandrasagar B. Dugani and Elsa Renee Flores and Paul W. Frankland and Sheena A. Josselyn and F. D. Miller and David R Kaplan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 31},
  pages={
          12569-85
        }
}
The molecular mechanisms that regulate adult neural precursor cell (NPC) survival, and thus maintain adult neurogenesis, are not well defined. Here, we investigate the role of p63, a p53 family member, in adult NPC function in mice. Conditional ablation of p63 in adult NPCs or p63 haploinsufficiency led to reduced numbers of NPCs and newborn neurons in the neurogenic zones of the hippocampus and lateral ventricles and in the olfactory bulb. These reductions were attributable to enhanced… CONTINUE READING

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