p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells

@article{Thompson2003p62OI,
  title={p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells},
  author={Herbert G. Thompson and Joseph W Harris and Barbara J. Wold and Fritz Lin and James P. Brody},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={2322-2333}
}
p62 is a multifunctional cytoplasmic protein able to noncovalently bind ubiquitin and several signaling proteins, suggesting a regulatory role connected to the ubiquitin–proteasome pathway. No studies to date have linked p62 protein expression with pathological states. Here we demonstrate the overabundance of p62 protein in malignant breast tissue relative to normal breast tissue. The proteasome inhibitor PSI increased p62 mRNA and protein; however, PSI treatment of breast epithelial cells… CONTINUE READING
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