p62 at the interface of autophagy, oxidative stress signaling, and cancer.

@article{Nezis2012p62AT,
  title={p62 at the interface of autophagy, oxidative stress signaling, and cancer.},
  author={Ioannis P. Nezis and Harald Stenmark},
  journal={Antioxidants & redox signaling},
  year={2012},
  volume={17 5},
  pages={786-93}
}
SIGNIFICANCE Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. RECENT ADVANCES Recent evidence has revealed that p62/SQSTM1 has a critical role in an oxidative stress response pathway by its direct interaction with the ubiquitin ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), which results in constitutive activation of the transcription factor NF-E2-related factor 2 (NRF2). CRITICAL… CONTINUE READING
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