p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration

@inproceedings{Jackson2017p62PM,
  title={p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration},
  author={Kasey L. Jackson and Wen-lang Lin and Sumitra Miriyala and Robert D. Dayton and Manikandan Panchatcharam and Kevin J McCarthy and Monica Castanedes-Casey and Dennis W. Dickson and Ronald L. Klein},
  booktitle={PloS one},
  year={2017}
}
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body myositis. Since p62 functions in protein degradation pathways including… CONTINUE READING