p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

  title={p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria},
  author={Kei Okatsu and Keiko Saisho and Midori Shimanuki and Kazuto Nakada and Hiroshi Shitara and Yu-shin Sou and Mayumi Kimura and Shigeto Sato and Nobutaka Hattori and M. Asaliaru Komatsu and Keiji Tanaka and Noriyuki Matsuda},
  booktitle={Genes to cells : devoted to molecular & cellular mechanisms},
PINK1 and Parkin were first identified as the causal genes responsible for familial forms of early-onset Parkinson's disease (PD), a prevalent neurodegenerative disorder. PINK1 encodes a mitochondrial serine/threonine protein kinase, whereas Parkin encodes an ubiquitin-protein ligase. PINK1 and Parkin cooperate to maintain mitochondrial integrity; however, the detailed molecular mechanism of how Parkin-catalyzed ubiquitylation results in mitochondrial integrity remains an enigma. In this study… CONTINUE READING
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