p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

  title={p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions},
  author={Yoshihisa Watanabe and Harutsugu Tatebe and Katsutoshi Taguchi and Yasuhisa Endo and Takahiko Tokuda and T Mizuno and Masanori Nakagawa and Masaki Tanaka},
  booktitle={PloS one},
α-Synuclein is the main component of Lewy bodies, the intraneuronal inclusion bodies characteristic of Parkinson's disease. Although α-synuclein accumulation is caused by inhibition of proteasome and autophagy-lysosome, the degradation of α-synuclein inclusions is still unknown. Formation of Lewy body-like inclusions can be replicated in cultured cells by introducing α-synuclein fibrils generated in vitro. We used this cell culture model to investigate the autophagy of α-synuclein inclusions… CONTINUE READING


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