p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina.

@article{Dyer2000p57Kip2RP,
  title={p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina.},
  author={Michael A. Dyer and Constance L. Cepko},
  journal={Development},
  year={2000},
  volume={127 16},
  pages={3593-605}
}
A precise balance between proliferation and differentiation must be maintained during retinal development to obtain the correct proportion of each of the seven cell types found in the adult tissue. Cyclin kinase inhibitors can regulate cell cycle exit coincident with induction of differentiation programs during development. We have found that the p57(Kip2) cyclin kinase inhibitor is upregulated during G(1)/G(0) in a subset of retinal progenitor cells exiting the cell cycle between embryonic day… CONTINUE READING