p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.

  title={p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.},
  author={Shinichi Okamura and Hirofumi Arakawa and Tomoaki Tanaka and Hiroshi Nakanishi and Chuo Chung Ng and Yoichi Taya and Masayo Monden and Yusuke Nakamura},
  journal={Molecular cell},
  volume={8 1},
Using the differential display method combined with a cell line that carries a well-controlled expression system for wild-type p53, we isolated a p53-inducible gene, termed p53DINP1 (p53-dependent damage-inducible nuclear protein 1). Cell death induced by DNA double-strand breaks (DSBs), as well as Ser46 phosphorylation of p53 and induction of p53AIP1, were blocked when we inhibited expression of p53DINP1 by means of an antisense oligonucleotide. Overexpression of p53DINP1 and DNA damage by… CONTINUE READING
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