p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.

@article{Park2005p53CSVAN,
  title={p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.},
  author={W R Park and Yusuke Nakamura},
  journal={Cancer research},
  year={2005},
  volume={65 4},
  pages={1197-206}
}
Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not fully understood. Here we report isolation of a novel p53 target gene, designated p53-inducible cell-survival factor (p53CSV). p53CSV contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced apoptosis, whereas overexpression protected cells from apoptosis caused by DNA damage… CONTINUE READING
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