p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy

@article{Junker2000p53TG,
  title={p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy},
  author={Klaus Junker and Th. Wiethege and K. -P. M{\"u}ller and Michael Thomas},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2000},
  volume={126},
  pages={238-245}
}
In a phase II study for optimizing therapeutic management of locally advanced non-small-cell lung cancer the prognostic and therapeutic relevance of the p53 status was investigated. Biopsy or mediastinoscopy samples, collected prior to neoadjuvant chemoradiotherapy and corresponding resection specimens, were analysed immunohistochemically (CM1 antiserum) for p53 accumulation and molecular biologically (polymerase chain reaction/single-strand conformation polymorphism) for p53 mutations. The… CONTINUE READING

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