p53 tumor suppressor gene mutations in transformed cutaneous T-cell lymphoma: a study of 12 cases.

@article{Marrogi1999p53TS,
  title={p53 tumor suppressor gene mutations in transformed cutaneous T-cell lymphoma: a study of 12 cases.},
  author={Aizen J. Marrogi and Mohammed Aamir Khan and Eric C. Vonderheid and Gary Stewart Wood and Elizabeth I. McBurney},
  journal={Journal of cutaneous pathology},
  year={1999},
  volume={26 8},
  pages={369-78}
}
The transformation of cutaneous T-cell lymphoma (t-CTCL) is an uncommon phenomenon that is associated with histopathologic changes and follows an aggressive course. The factors contributing to this transformation are poorly understood. The aim of this study was to analyze the p53 status in t-CTCL and to correlate it with disease outcome. The p53 status was investigated by immunohistochemistry, single-strand conformation polymorphism (SSCP) and DNA sequencing in 12 patients with t-CTCL. Eight… CONTINUE READING

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