p53 tumor-suppressor gene: clues to molecular carcinogenesis.

  title={p53 tumor-suppressor gene: clues to molecular carcinogenesis.},
  author={Xin Wei Wang and Curtis C. Harris},
  journal={Journal of cellular physiology},
  volume={173 2},
The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. The p53 is functionally inactivated by mutational, viral, and cellular mechanisms in the majority of human cancers. Analysis of the spectrum of p53 mutations provides clues to the etiology and molecular pathogenesis of cancer. Recent insight into the p53-mediated… CONTINUE READING

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