p53 suppresses the self-renewal of adult neural stem cells.

Abstract

There is increasing evidence that tumors are heterogeneous and that a subset of cells act as cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of stem cell function, suggesting that similar mechanisms control normal and cancer stem cell properties. We show here that the prototypical tumor suppressor p53, which plays an… (More)

5 Figures and Tables

Topics

  • Presentations referencing similar topics