p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

Abstract

Cells respond to the shift of intracellular environment toward pro-oxidant conditions by activating the transcription of numerous "antioxidant" genes. This response is based on the activation of the Nrf2 transcription factor, which transactivates the genes containing in their promoters the antioxidant response cis-elements (AREs). If the oxidative stress… (More)

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@article{Faraonio2006p53ST, title={p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.}, author={Raffaella Faraonio and Paola Vergara and Domenico Di Marzo and Maria Giovanna Pierantoni and Maria Rosaria Napolitano and Tommaso Russo and Filiberto Cimino}, journal={The Journal of biological chemistry}, year={2006}, volume={281 52}, pages={39776-84} }