p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

@inproceedings{Akeno2015p53SC,
  title={p53 suppresses carcinoma progression by inhibiting mTOR pathway activation},
  author={Nagako Akeno and Ashley L. Miller and Xiaolan Ma and Kathryn Wikenheiser-brokamp},
  booktitle={Oncogene},
  year={2015}
}
Genetic alterations in human cancers and murine models indicate that retinoblastoma (Rb) and p53 have critical tumor suppressive functions in retinoblastoma, a tumor of neural origin, and neuroendocrine tumors including small cell lung cancer and medullary thyroid cancer (MTC). Rb inactivation is the initiating lesion in retinoblastoma and current models propose that induction of apoptosis is a key p53 tumor suppressive function. Genetic studies in mice, however, indicate that other undefined… CONTINUE READING
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