p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.

@article{Mukhopadhyay2009p53SS,
  title={p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.},
  author={Utpal K. Mukhopadhyay and Robert Eves and Lilly Jia and Patrick Mooney and Alan S. Mak},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 11},
  pages={3088-98}
}
The tumor-suppressive role of p53 at the level of tumor initiation is well documented. It has also been shown previously that p53 acts against tumor progression/metastasis. However, its role in modulating cell migration and invasion leading to metastasis is poorly understood. In this study, using vascular smooth muscle cells and NIH 3T3 fibroblast cells, we have shown that p53 potently suppresses Src-induced podosome/rosette formation, extracellular matrix digestion, cell migration, and… CONTINUE READING

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