p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53.

@article{Shin1995p53ST,
  title={p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53.},
  author={Tae Ho Shin and Andrew W J Paterson and Jeffrey E. Kudlow},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 9},
  pages={4694-701}
}
Physical and chemical agents can damage the genome. Part of the protective response to this damage is the increased expression of p53. p53, a transcription factor, controls the expression of genes, leading to cell cycle arrest and apoptosis. Another protective mechanism is the proliferative response required to replace the damaged cells. This proliferation is likely to be signaled by growth factors. In this communication, we show that the transforming growth factor alpha (TGF-alpha) gene is a… CONTINUE READING