p53 stabilization and transactivation by a von Hippel-Lindau protein.

@article{Roe2006p53SA,
  title={p53 stabilization and transactivation by a von Hippel-Lindau protein.},
  author={Jae-Seok Roe and Hyungsoo Kim and Seokjoon Lee and Sung-Tae Kim and Eun-Jung Cho and Hong-Duk Youn},
  journal={Molecular cell},
  year={2006},
  volume={22 3},
  pages={
          395-405
        }
}
von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome. Although hypoxia-inducible factor-alpha (HIFalpha) is a well-documented substrate of von Hippel-Lindau tumor suppressor protein (pVHL), it remains unclear whether the dysregulation of HIF is sufficient to account for de novo tumorigenesis in VHL-deleted cells. Here we found that pVHL directly associates with and stabilizes p53 by suppressing Mdm2-mediated ubiquitination and nuclear export of p53. Moreover, upon… CONTINUE READING

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