p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species.

@article{Hu2013p53SC,
  title={p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species.},
  author={Weilin Hu and Yumei Ge and David M. Ojcius and Dexter Y. Sun and Haiyan Dong and X Frank Yang and Jie Yan},
  journal={Cellular microbiology},
  year={2013},
  volume={15 10},
  pages={
          1642-59
        }
}
Pathogenic Leptospira species, the causative agents of leptospirosis, have been shown to induce macrophage apoptosis through caspase-independent, mitochondrion-related apoptosis inducing factor (AIF) and endonuclease G (EndoG), but the signalling pathway leading to AIF/EndoG-based macrophage apoptosis remains unknown. Here we show that infection of Leptospira interrogans caused a rapid increase in reactive oxygen species (ROS), DNA damage, and intranuclear foci of 53BP1 and phosphorylation of… CONTINUE READING
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