• DOI:10.1038/nature05993
Corpus ID: 4357527

p53 regulates maternal reproduction through LIF

@article{Hu2007p53RM,
  title={p53 regulates maternal reproduction through LIF},
  author={Wenwei Hu and Z. Feng and A. Teresky and A. Levine},
  journal={Nature},
  year={2007},
  volume={450},
  pages={721-724}
}

Wenwei Hu, Z. Feng, +1 author A. Levine

Published 2007

Biology, Medicine

Nature

Extensive studies have shown that p53 is important in tumour prevention. However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner. Significant decreases in embryonic implantation, pregnancy rate and litter size were observed in matings with p53-/- female mice but not with p53-/- male mice. The gene encoding leukaemia inhibitory factor (LIF), a cytokine critical for implantation, was identified as a p53… CONTINUE READING

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