p53 regulates maternal reproduction through LIF

  title={p53 regulates maternal reproduction through LIF},
  author={Wenwei Hu and Z. Feng and A. Teresky and A. Levine},
  • Wenwei Hu, Z. Feng, +1 author A. Levine
  • Published 2007
  • Biology, Medicine
  • Nature
  • Extensive studies have shown that p53 is important in tumour prevention. However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner. Significant decreases in embryonic implantation, pregnancy rate and litter size were observed in matings with p53-/- female mice but not with p53-/- male mice. The gene encoding leukaemia inhibitory factor (LIF), a cytokine critical for implantation, was identified as a p53… CONTINUE READING
    382 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    p53: A new player in reproduction
    • 77
    Regulation of female reproduction by p53 and its family members
    • Z. Feng, C. Zhang, +8 authors W. Hu
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2011
    • 75
    Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans
    • 178
    • PDF
    Regulation of Fertility by the p53 Family Members.
    • 31
    The role of p53 gene family in reproduction.
    • W. Hu
    • Biology, Medicine
    • Cold Spring Harbor perspectives in biology
    • 2009
    • 59
    • PDF
    Mouse Double Minute 2 Actively Suppresses p53 Activity in Oocytes during Mouse Folliculogenesis.
    • 2
    Mouse Models of p 53 Functions
    • 6
    • PDF
    Mouse models of p53 functions.
    • G. Lozano
    • Biology, Medicine
    • Cold Spring Harbor perspectives in biology
    • 2010
    • 89
    • PDF


    p53 and E2F-1 cooperate to mediate apoptosis.
    • X. Wu, A. Levine
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1994
    • 873
    • PDF
    Polymorphic variants in the p53 pathway
    • M. Murphy
    • Biology, Medicine
    • Cell Death and Differentiation
    • 2006
    • 85