p53 regulates maternal reproduction through LIF

@article{Hu2007p53RM,
  title={p53 regulates maternal reproduction through LIF},
  author={Wenwei Hu and Z. Feng and A. Teresky and A. Levine},
  journal={Nature},
  year={2007},
  volume={450},
  pages={721-724}
}
  • Wenwei Hu, Z. Feng, +1 author A. Levine
  • Published 2007
  • Medicine, Biology
  • Nature
  • Extensive studies have shown that p53 is important in tumour prevention. However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner. Significant decreases in embryonic implantation, pregnancy rate and litter size were observed in matings with p53-/- female mice but not with p53-/- male mice. The gene encoding leukaemia inhibitory factor (LIF), a cytokine critical for implantation, was identified as a p53… CONTINUE READING
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