p53 regulates maternal reproduction through LIF
@article{Hu2007p53RM, title={p53 regulates maternal reproduction through LIF}, author={Wenwei Hu and Z. Feng and A. Teresky and A. Levine}, journal={Nature}, year={2007}, volume={450}, pages={721-724} }
Extensive studies have shown that p53 is important in tumour prevention. However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner. Significant decreases in embryonic implantation, pregnancy rate and litter size were observed in matings with p53-/- female mice but not with p53-/- male mice. The gene encoding leukaemia inhibitory factor (LIF), a cytokine critical for implantation, was identified as a p53… CONTINUE READING
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- 2010
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- Proceedings of the National Academy of Sciences
- 2009
- 178
- PDF
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- 2009
- 59
- PDF
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References
SHOWING 1-10 OF 22 REFERENCES
High-frequency developmental abnormalities in p53-deficient mice
- Biology, Medicine
- Current Biology
- 1995
- 458
- PDF
Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis.
- Biology, Medicine
- Endocrinology
- 2000
- 262
- PDF
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
- Biology, Medicine
- Nature
- 1992
- 1,910
Multiple alternate p21 transcripts are regulated by p53 in human cells
- Biology, Medicine
- Oncogene
- 2006
- 42
- PDF
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.
- Biology, Medicine
- Genes & development
- 1991
- 432
- PDF
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.
- Biology, Medicine
- Genes & development
- 1996
- 743
- PDF
p53 and E2F-1 cooperate to mediate apoptosis.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1994
- 873
- PDF
Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1996
- 392
- PDF