p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

@article{Sawada2001p53RC,
  title={p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells},
  author={Motoshi Sawada and Shigeru Nakashima and Tohru Kiyono and Masanori Nakagawa and Jun Yamada and Haruki Yamakawa and Y. Banno and Jun Shinoda and Yasuaki Nishimura and Yoshinori Nozawa and N Sakai},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={1368-1378}
}
The present study was designed to elucidate the relationship between p53 and ceramide, both of which are involved in apoptotic signaling. Treatment of human glioma cells with etoposide caused apoptosis only in cells expressing functional p53. p53 activation was followed by the formation of reactive oxygen species (ROS), superoxide anion (O2−•) measured by hydroethidium oxidation into ethidium and hydrogen peroxide (H2O2) measured by oxidation of 2′,7′-dichlorofluorescin (DCFH) into 2′,7… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-5 of 5 references

Immunol

  • G Kroemer, N Zamzami, SA. Susin
  • Today, 18, 45 ± 51.
  • 1997

J

  • P Zhang, B Liu, GM Jenkins, YA Hannun, LM. Obeid
  • Biol. Chem., 272, 9609 ± 9612.
  • 1997

Trend Biochem

  • Jacobson
  • Sci., 21, 83 ± 86.
  • 1996
1 Excerpt

Proc

  • JL Vayssiere, PX Petit, Y Risler, B. Mignotte
  • Natl. Acad. Sci. USA, 91, 11752 ± 11756.
  • 1994

Br

  • C. Borek
  • J. Cancer, 8, S74 ± S86.
  • 1987
1 Excerpt

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