p53 regulates autophagic activity in senescent rat mesenchymal stromal cells.


The tumor suppressor protein p53 is an important player in the regulation of cell senescence, its functions are largely carried out by modulating its downstream genes. Emerging evidence has suggested that senescence and autophagy appear to be regulated by overlapping signaling pathways. Furthermore, autophagy markers have been observed in senescent cells… (More)
DOI: 10.1016/j.exger.2016.01.004