p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells

@article{Wang2011p53RK,
  title={p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells},
  author={Mei-juan Wang and Dongsheng Pei and Guo-Wei Qian and Xiao-xing Yin and Qian Cheng and Lian-Tao Li and Hui-Zhong Li and Jun-nian Zheng},
  journal={Tumor Biology},
  year={2011},
  volume={32},
  pages={905-912}
}
The expression of the human Ki-67 protein, which is strictly associated with cell proliferation, is regulated by a variety of cellular mediators. In this study, we studied the effects of p53 on Ki-67 promoter in HeLa cells using luciferase reporter assay. The results showed that: (1) p53 inhibited Ki-67 promoter activity in a dose-dependent manner, (2) the p53-binding motifs mediated part of the transcriptional repression of Ki-67 promoter through a sequence-specific interaction with p53, (3… CONTINUE READING

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H Tian, GW Qian, +3 authors DS Pei
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