p53 regulates FAK expression in human tumor cells.

  title={p53 regulates FAK expression in human tumor cells.},
  author={Vita M. Golubovskaya and Richard A Finch and Frederick A Kweh and Nicole A. Massoll and Martha Campbell-Thompson and Margaret R. Wallace and William Cance},
  journal={Molecular carcinogenesis},
  volume={47 5},
Attenuation of the p53 protein is one of the most common abnormalities in human tumors. Another important marker of tumorigenesis is focal adhesion kinase (FAK), a 125-kDa tyrosine kinase that is overexpressed at the mRNA and protein levels in a variety of human tumors. FAK is a critical regulator of adhesion, motility, metastasis, and survival signaling. We have characterized the FAK promoter and demonstrated that p53 can inhibit the FAK promoter activity in vitro. In the present study, we… CONTINUE READING
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