p53 reactivation

@inproceedings{DOrazi2012p53R,
  title={p53 reactivation},
  author={Gabriella D’Orazi and David Givol},
  booktitle={Cell cycle},
  year={2012}
}
Lack of p53 expression or expression of mutant p53 is common in human cancers and is associated with increased tumor growth and resistance to therapies. 1 Significant efforts toward pharmaceutical reactivation of defective p53 by small molecules are therefore underway, targeting the different means that inactivate p53. 2,3 Indeed, reactivated p53 can lead to tumor destruction. 4 A recent paper in Cancer Cell by Yu et al. describes reactivation of mutant p53 (mtp53) by thiosemicarbazone… CONTINUE READING
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