p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma.

@article{Harpaz1994p53PE,
  title={p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma.},
  author={Noam H Harpaz and Anat Peck and Jian-ning Yin and Isabel M Fiel and M Hontanosas and Tommy Richard Sun-wing Tong and Jan Laurin and John M. Abraham and Bruce D. Greenwald and Stephen J. Meltzer},
  journal={Human pathology},
  year={1994},
  volume={25 10},
  pages={1069-74}
}
The frequency and timing of p53 inactivation in ulcerative colitis (UC)-associated tumorigenesis were investigated using immunohistochemistry (IHC) to detect p53 protein overexpression in 56 carcinomas and 40 dysplastic epithelia derived from 58 patients with UC undergoing colectomy for neoplasia. p53 DNA in 25 of the carcinomas also was evaluated by single-strand conformation polymorphism analysis (SSCP) to detect point mutations in exons 5-8 and by loss of heterozygosity analysis to detect… CONTINUE READING

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The molecular landscape of colitis-associated carcinogenesis.

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