p53 protein expression in central nervous system neoplasms.

  title={p53 protein expression in central nervous system neoplasms.},
  author={Mattia Barbareschi and Paolo Iuzzolino and Antonio Pennella and Antonio Allegranza and Gianluigi Arrigoni and Paolo Dalla Palma and Claudio Doglioni},
  journal={Journal of clinical pathology},
  volume={45 7},
AIMS To demonstrate, immunohistochemically, p53 protein expression in a selection of central nervous system tumours; to investigate the relation between p53 expression and that of the proliferation related antigen, PCNA. METHODS Surgical specimens from 86 central nervous system tumours were routinely fixed, paraffin wax embedded, and immunostained with a monoclonal (PAb 1801) and a policlonal antibody (CM1) p53 protein and a monoclonal antibody against PCNA (PC10). Normal brain samples… CONTINUE READING


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